Stable Human Fc Receptor--Transformed Cell Lines to Detect Virus-Neutralizing and Enhancing Antibodies

Institution: University of Rochester

Summary
The invention offers a novel method to screen anti-flavivirus antibodies in blood for neutralizing and replication-enhancing antibodies using Fc gamma R transformed macrophages.

Advantage
The invention offers simplicity and the prospect of an automated, high through-put alternative to both conventional virus plaque neutralization and immune enhancement assay. The method will offer a standardized format to replace current laborious methods to measure protective neutralizing and potentially undesirable immune-enhancing antibodies stimulated by natural infection or by candidate and established viral vaccine.

Inventor
Jacob Schlesinger

Category
Vaccines/Preventive Medicine:Vaccine Development Tools

Contact Information
Harl Tolbert
harl_tolbert@urmc.rochester.edu
http://urmc.rochester.edu/technology-transfer/find-technologies/index.cfm?TechnolID=138587